Bayesian inference in two‐arm trials using relative belief ratios

Various methodologies proposed for some inference problems associated with two‐arm trails are known to suffer from difficulties, as documented in Senn (2001). We propose an alternative Bayesian approach to these problems that deals with these difficulties through providing an explicit measure of statistical evidence and the strength of this evidence. Bayesian methods are often criticized for their intrinsic subjectivity. We show how these concerns can be dealt with through assessing the bias induced by a prior model checking and checking for prior‐data conflict. Copyright © 2015 John Wiley & Sons, Ltd.

Source: Pharmaceutical Statistics - July 1, 2015 Category: Statistics Authors: Saman Muthukumarana, Michael Evans Tags: Main Paper Source Type: research