Phytosome: A Fatty Solution for Efficient Formulation of Phytopharmaceuticals.

Phytosome: A Fatty Solution for Efficient Formulation of Phytopharmaceuticals. Recent Pat Drug Deliv Formul. 2015 Aug 13; Authors: Shakeri A, Sahebkar A Abstract During the past two decades, it has become well-known that phytomedicines could be successfully employed to treat several types of human diseases.However, low systemic bioavailability is commonly referred to as a major obstacle to achieve the maximum efficacy of phytomedicines in clinical practice. This low bioavailability is mainly due to either highly polar and water soluble, or strong lipophilic natureof some phytochemicals, causing hydrophilic lipophilic balance values that hinder complete passage of phytochemical through either unstirred water layer covering brush border or plasma membrane of enterocytes [1]. To overcome these limitations,majoradvances have been made using novel drug delivery systems [2]. Phytosome is a biocompatible and biodegradable delivery system that is formed through complexation -in an stoichiometricratio- of a phytochemical, or a mixture of phytochemicals, with a phospholipid, mainly phosphatidylcholine or phosphatidylserine, in an aprotic solvent [3] (Figure). The resulting complex will be then isolated using solvent precipitation. Phytosome is a patented technology by Indena S.p.A. (Milan, Italy), a leading supplier of phytopharmaceuticals and nutraceuticals. Unique physicochemical properties of phospholipids confer phytosomes an amphiphilic n...
Source: Recent Patents on Drug Delivery and Formulation - Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research