Design of symmetric TIM barrel proteins from first principles
Conclusions:
Despite the detection of molten characteristics, the creation of a soluble, cooperatively folding protein represents an advancement over previous attempts at TIM barrel design. Strategies to further improve Symmetrin-1 are elaborated. Our techniques may be used to create other large, internally symmetric proteins.
Source: BMC Biochemistry - Category: Biochemistry Authors: Deepesh NagarajanGeeta DekaMegha Rao Source Type: research