Radiosensitizing potential of Plumbagin in B16F1 melanoma tumor cells through mitochondrial mediated programmed cell death

In conclusion, this study demonstrates the radiosensitizing potential of PLB to inhibit the growth of melanoma cells in vitro, which may be attributed to the oxidative stress and DNA damage leading to enhanced mitochondria-mediated programmed cell death resulting in cell death. Also, this study demonstrate the ability of PLB to augment ionizing radiation induced tumor cell kill further warrant the avenue for the development of a clinically useful radiosensitizer. Graphical abstract
Source: Journal of Applied Biomedicine - Category: Biotechnology Source Type: research