p38 phosphorylation in medullary microglia mediates ectopic orofacial inflammatory pain in rats

Conclusions: These findings indicate that microglia, activated via p38 phosphorylation, play a pivotal role in WDR neuronal hyperexcitability, which accounts for the mechanical hypersensitivity in the lateral facial skin associated with trapezius muscle inflammation.

http://www.molecularpain.com/content/11/1/48

Source: Molecular Pain - August 12, 2015 Category: Molecular Biology Authors: Masaaki KiyomotoMasamichi ShinodaKuniya HondaYuka NakayaKo DezawaAyano KatagiriSatoshi KamakuraTomio InoueKoichi Iwata Source Type: research