Metformin Suppresses Prostaglandin E2-Induced Cytochrome P450 Aromatase Gene Expression and Activity via Stimulation of AMP-Activated Protein Kinase in Human Endometriotic Stromal Cells

Conclusion: Metformin could inhibit PGE2-induced CYP19A1 mRNA expression and aromatase activity via AMPK activation and inhibition of CREB to CYP19A1 PII in human ESCs. The results of the present study suggest that metformin may have unique therapeutic potential as an antiendometriotic drug in the future.

http://rsx.sagepub.com/cgi/content/abstract/22/9/1162?rss=1

Source: Reproductive Sciences - August 10, 2015 Category: Reproduction Medicine Authors: Zhou, Y., Xu, J.-N., Zeng, C., Li, X., Zhou, Y.-F., Qi, Y., Xue, Q. Tags: Original Articles Source Type: research