Mammalian target of Rapamycin inhibition and mycobacterial survival are uncoupled in murine macrophages
Conclusions:
This data, coupled with previous work from our laboratory, further indicates that autophagy induction by mTOR inhibition is an artificial means to increase mycobacterial killing and masks more relevant endogenous autophagic biochemistry that needs to be understood.
Source: BMC Biochemistry - Category: Biochemistry Authors: Alfred ZulloKristen Jurcic SmithSunhee Lee Source Type: research