Quantitation of a spin polarization‐induced nuclear Overhauser effect (SPINOE) between a hyperpolarized 13C‐labeled cell metabolite and water protons

The spin polarization‐induced nuclear Overhauser effect (SPINOE) describes the enhancement of spin polarization of solvent nuclei by the hyperpolarized spins of a solute. In this communication we demonstrate that SPINOEs can be observed between [1,4‐13C2]fumarate, hyperpolarized using the dissolution dynamic nuclear polarization technique, and solvent water protons. We derive a theoretical expression for the expected enhancement and demonstrate that this fits well with experimental measurements. Although the magnitude of the effect is relatively small (around 2% measured here), the SPINOE increases at lower field strengths, so that at clinically relevant magnetic fields (1.5–3 T) it may be possible to track the passage through the circulation of a bolus containing a hyperpolarized 13C‐labeled substrate through the increase in solvent water 1H signal. © 2014 The Authors. Contrast Media & Molecular Imaging published by John Wiley and Sons, Ltd.
A theoretical expression for the expected SPINOE enhancement of solvent protons in an aqueous solution of hyperpolarized [1,413C2]fumarate and its experimental validation are presented.

Source: Contrast Media and Molecular Imaging - February 12, 2014 Category: Radiology Authors: Irene Marco‐Rius, Sarah E. Bohndiek, Mikko I. Kettunen, Timothy J. Larkin, Meer Basharat, Colm Seeley, Kevin M. Brindle Tags: Short Communication Source Type: research