Multimodal cell tracking of a spontaneous metastasis model: comparison between MRI, electron paramagnetic resonance and bioluminescence

In conclusion, EPR is well adapted to ex vivo analysis of tissues after cell tracking experiments and allows short‐term monitoring of metastasizing cells. MRI is a suitable tool for checking labelled cells at their injection site, but dilution of the iron oxides owing to cell division remains a major limitation. BLI remains the most suitable technique for long‐term monitoring of metastatic cells. Copyright © 2014 John Wiley & Sons, Ltd. Ex vivo electron paramagnetic resonance allows short‐term cell tracking of iron oxide‐labeled metastatic cancer cells whereas bioluminescence imaging allows long‐term monitoring of cells. Magnetic resonance imaging is suitable labeled cells to be checked (hypointense spot on T2‐, T2*‐weighted images) at their injection site.
Source: Contrast Media and Molecular Imaging - Category: Radiology Authors: Tags: Full Paper Source Type: research