Chitinase-3-like protein 1 protects skeletal muscle from TNF{alpha}-induced inflammation and insulin resistance

In conclusion, the novel myokine CHI3L1 which is induced by pro-inflammatory cytokines can counteract TNFα-mediated inflammation and insulin resistance in human skeletal muscle cells, potentially involving an auto/paracrine mechanism.

Source: BJ Cell - February 11, 2014 Category: Biochemistry Authors: S W. Görgens, K Eckardt, M Elsen, N Tennagels, J Eckel Tags: BJ Metabolism Source Type: research