Comparing α7 Nicotinic Acetylcholine Receptor Binding, Amyloid‐β Deposition, and Mitochondria Complex‐I Function in Living Brain: A PET Study in Aged Monkeys

This article is protected by copyright. All rights reserved. Effects of amyloid‐β (Aβ) deposition on α7 nicotinic acetylcholine receptor (α7‐nAChR) binding and on mitochondrial complex‐I (MC‐I) activity were assessed in the brain of aged monkeys (Macaca mulatta). PET measurements with [11C](R)‐MeQAA forα7‐nAChR binding, [11C]PIB for Aβ, and [18F]BCPP‐EF for MC‐I were conducted in monkeys in a conscious condition.
Source: Synapse - Category: Neurology Authors: Tags: Research Article Source Type: research