Comparing α7 Nicotinic Acetylcholine Receptor Binding, Amyloid‐β Deposition, and Mitochondria Complex‐I Function in Living Brain: A PET Study in Aged Monkeys
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Effects of amyloid‐β (Aβ) deposition on α7 nicotinic acetylcholine receptor (α7‐nAChR) binding and on mitochondrial complex‐I (MC‐I) activity were assessed in the brain of aged monkeys (Macaca mulatta). PET measurements with [11C](R)‐MeQAA forα7‐nAChR binding, [11C]PIB for Aβ, and [18F]BCPP‐EF for MC‐I were conducted in monkeys in a conscious condition.
Source: Synapse - Category: Neurology Authors: Shingo Nishiyama, Hiroyuki Ohba, Masakatsu Kanazawa, Takeharu Kakiuchi, Hideo Tsukada Tags: Research Article Source Type: research