A Toll‐Like Receptor 1/2 Agonist Augments Contractility in Rat Corpus Cavernosum

ConclusionsThe TLR1/2 heterodimer mediates augmented contraction and reduced relaxation in rat cavernosal strips. Thus, TLR1/2 activation antagonizes vascular responses crucial for normal erectile function and implicates immune activation in vasculogenic erectile dysfunction. Immune signaling via TLR2 may offer novel targets for treating inflammation‐mediated vascular dysfunction in the penis. Stallmann‐Jorgensen I, Ogbi S, Szasz T, and Webb RC. A Toll‐like receptor 1/2 agonist augments contractility in rat corpus cavernosum. J Sex Med **;**:**–**.

Source: The Journal of Sexual Medicine - July 31, 2015 Category: Sexual Medicine Authors: Inger Stallmann‐Jorgensen, Safia Ogbi, Theodora Szasz, R. Clinton Webb Tags: Original Research Source Type: research