Skeletal muscle to pancreatic β-cell cross-talk: the effect of humoral mediators liberated by muscle contraction and acute exercise on β-cell apoptosis.

CONCLUSIONS: Unidentified circulating humoral mediators released during exercise prevent proinflammatory cytokine-induced β-cell apoptosis. Muscle-derived mediators released during exercise suppress β-cell insulin secretion. Furthermore, muscle-derived IL-6 appears to prevent β-cell apoptosis under normal conditions but contributes to β-cell apoptosis under proinflammatory conditions. PMID: 26218753 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/26218753?dopt=Abstract

Source: Diabetes Metab - July 28, 2015 Category: Endocrinology Authors: Christensen CS, Christensen DP, Lundh M, Dahllöf MS, Haase TN, Velasquez JM, Laye MJ, Mandrup-Poulsen T, Solomon TP Tags: J Clin Endocrinol Metab Source Type: research