Differential roles of tryptophan residues in conformational stability of Porphyromonas gingivalis HmuY hemophore

Conclusions:
Here we demonstrate differential roles of tryptophan residues in the protein conformational stability. We also propose different conformations of apo- and holoHmuY caused by tertiary changes which allow heme binding to the protein.

Source: BMC Biochemistry - February 10, 2014 Category: Biochemistry Authors: Marcin BieleckiHalina WójtowiczTeresa Olczak Source Type: research