Mechanisms of enterohepatic fibroblast growth factor 15/19 signaling in health and disease

The human Fibroblast Growth Factor (FGF) family comprises 18 members of extracellular signaling molecules that act as key regulators of diverse cellular functions under a plethora of different physiological and pathological conditions. FGFs are typically classified into six subfamilies based on sequence homology and functional properties. Most FGFs share conserved heparan sulfate glycosaminoglycan (HSGAG) binding sites (HBS) that rapidly interact with cell surface receptors in close vicinity to the site of their release.
Source: Cytokine and Growth Factor Reviews - Category: Molecular Biology Authors: Tags: Mini review Source Type: research