Peritoneal dialysis-associated peritonitis caused by vancomycin-resistant Enterococcus: Comprehensive review on treatment options

Publication date: Available online 26 July 2015 Source:Hong Kong Journal of Nephrology Author(s): Chi-kwan Lam, Siu-kim Chan, Yiu-wing Ho, Sin-man Li, Chun-hay Tam, Anthony Wing-chung Tang, Sze-ho Wong Vancomycin-resistant enterococci have emerged as a global health care threat and their occurrence in peritoneal dialysis-related peritonitis is a challenging condition for nephrologists because the treatment options are limited. In this review, we will discuss the established efficacy of linezolid, quinupristin/dalfopristin (Q/P), daptomycin, and the potential use of tigecycline in treating this condition. Because experience in treating this condition is extremely limited and there is a lack of well-constructed clinical trials on different treatment options, case reports/series were adopted for descriptive analysis. The treatment strategy in olden days involved using Q/P (switching to linezolid in case of treatment failures), whereas recent case reports have described successful use of daptomycin with preservation of the dialysis catheter in all cases. However, more studies are required to confirm the superiority of any one of these options in treating this specific condition. 抗萬古黴素腸球菌(vancomycin-resistant Enterococcus)已發展成一個全球性的公共衛生威脅,其所導致的腹膜透析相關腹膜炎基於治療選項有限,對腎科醫生更是一大挑戰。在本文中我們將回顧linezolid、quinupristin/dalfopristin (Q/P)、及d...
Source: Hong Kong Journal of Nephrology - Category: Urology & Nephrology Source Type: research