Future Prospects for the Treatment of Graves' Hyperthyroidism and Eye Disease.

Future Prospects for the Treatment of Graves' Hyperthyroidism and Eye Disease.
Horm Metab Res. 2015 Jul 21;
Authors: Neumann S, Place RF, Krieger CC, Gershengorn MC
Abstract
Although there are adequate therapies for Graves' hyperthyroidism, mild to moderate Graves' orbitopathy (GO) is usually treated symptomatically whereas definitive therapy is reserved for severe, vision-threatening GO. Importantly, none of the treatment regimens for Graves' disease used today are directed at the pathogenesis of the disease. Herein, we review some aspects of what is known about the pathogenesis of these 2 major components of Graves' disease, specifically the apparent important roles of the TSH and IGF-1 receptors, and thereafter describe future therapeutic approaches directed at these receptors. We propose that targeting these receptors will yield effective and better tolerated treatments for Graves' disease, especially for GO.
PMID: 26197854 [PubMed - as supplied by publisher]

Source: Diabetes Metab - July 21, 2015 Category: Endocrinology Authors: Neumann S, Place RF, Krieger CC, Gershengorn MC Tags: Horm Metab Res Source Type: research