Design of an allele-specific PCR assay to genotype the rs12255372 SNP in a pilot study of association between common TCF7L2 polymorphisms and type 2 diabetes in Venezuelans.
Conclusions We developed a novel allele-specific PCR method for easier and rapid detection of rs12255372 polymorphism without the use of expensive instrumentation and reagents. Our study in a relatively small sample of the Venezuelan population replicated the association of the rs7903146 SNP with T2DM. Further studies with larger sample size and more biochemical data should be conducted to explore the genetic basis of T2DM susceptibility in Venezuela.
PMID: 26201011 [PubMed - as supplied by publisher]
Source: Diabetes Metab - Category: Endocrinology Authors: Moran Y, Labrador L, Camargo ME, Fernández D, Chiurillo MA Tags: Arch Endocrinol Metab Source Type: research
More News: Diabetes | Diabetes Mellitus | Diabetes Type 2 | Endocrinology | Genetics | Statistics | Study | Venezuela Health