PreImplantation Factor (PIF*) Endogenously Prevents Preeclampsia: Promotes Trophoblast Invasion and Reduces Oxidative Stress

Effective embryo/maternal communication is the key for successful pregnancy, and it becomes operative starting already just post-fertilization. Conversely, very early defective signaling can lead to failed implantation, may cause miscarriage, IUGR and/or preeclampsia (PE). The zona-pellucida is a semi-permeable protective barrier which enables embryo specific signals to condition the mother.(Barnea, 2014)
Source: Journal of Reproductive Immunology - Category: Allergy & Immunology Authors: Source Type: research