Non-Immune Hemolysis: Diagnostic Considerations

Non immune hemolytic anemia (NIHA) is characterised by positive routine hemolytic tests but negative antihuman immunoglobulin (Coombs) test. Hereditary non immune hemolysis includes disorders of erythrocytic enzymes, membrane, hemoglobin (qualitative and quantitative disorders) as well as the rare hereditary forms of thrombotic microangiopathies. Acquired NIHA includes PNH, infections, drug and metal intoxications with as a target red blood cells or endothelium of capillaries, the rare acquired forms of thalassemia or erythrocytic membrane disorders, hemolysis secondary to a dysfunctioning artificial (prosthetic) cardiac valve.

Source: Seminars in Hematology - July 20, 2015 Category: Hematology Authors: Photis Beris, Véronique Picard Source Type: research