Visualization of delayed release of compounds from pH‐sensitive capsules in vitro and in vivo in a hamster model

In conclusion, we propose combined 19 F‐MRI and CT to non‐invasively visualize the different temporal and spatial events regarding the release of compounds, both in an in vitro setting and in the gastrointestinal tract of small animal models. This multimodal imaging approach will enable the in vitro and in vivo evaluation of further technical improvements to controlled release strategies. Copyright © 2015 John Wiley & Sons, Ltd. Combined imaging allows non‐invasive visualization of the delivery and release of compounds to the intestinal tract. We have monitored the integrity of pH‐sensitive polymer capsules and the release of contrast agents (19 F‐FDG and BaSO4) from the capsules in vivo in a proof‐of‐principle study using 19 F‐MRI and CT. This multimodal imaging approach will enable the in vitro and in vivo evaluation of novel delivery and controlled release strategies.
Source: Contrast Media and Molecular Imaging - Category: Radiology Authors: Tags: Full paper Source Type: research