Alternative signaling network activation through different insulin receptor family members caused by pro-mitogenic antidiabetic insulin analogues in human mammary epithelial cells

Conclusions:
We propose that these mitogenic classifier genes can be used to test the mitogenic potential of novel insulin analogues as well as other alternative molecules with an anticipated affinity for the IGF1R.

Source: Breast Cancer Research - July 19, 2015 Category: Cancer & Oncology Authors: Bas ter BraakSteven WinkEsmee KoedootChantal PontChristine SiezenJan van der LaanBob van de Water Source Type: research