Towards integrative systems pharmacology models in oncology drug development

Publication date: August 2015 Source:Drug Discovery Today: Technologies, Volume 15 Author(s): J.G. Coen van Hasselt, Piet H. van der Graaf Quantitative systems pharmacology (QSP) modeling represents an emerging area of value to further streamline knowledge integration and to better inform decision making processes in drug development. QSP models reside at the interface between systems biology models and pharmacological models, yet their concrete implementation still needs to be established further. This review outlines key modeling techniques in both of these areas and to subsequently discuss challenges and opportunities for further integration, in oncology drug development.
Source: Drug Discovery Today: Technologies - Category: Drugs & Pharmacology Source Type: research