PEA3 transcription factors are downstream effectors of Met signaling involved in migration and invasiveness of Met-addicted tumor cells

Various solid tumors including lung or gastric carcinomas display aberrant activation of the Met receptor which correlates with aggressive phenotypes and poor prognosis. Although downstream signaling of Met is well described, its integration at the transcriptional level is poorly understood. We demonstrate here that in cancer cells harboring met gene amplification, inhibition of Met activity with tyrosine kinase inhibitors or specific siRNA drastically decreased expression of ETV1, ETV4 and ETV5, three transcription factors constituting the PEA3 subgroup of the ETS family, while expression of the other members of the family were less or not affected.

Source: Molecular Oncology - July 15, 2015 Category: Cancer & Oncology Authors: Zoulika Kherrouche, Didier Monte, Elisabeth Werkmeister, Luc Stoven, Yvan De Launoit, Alexis B. Cortot, David Tulasne, Anne Chotteau-Lelievre Source Type: research