Does Zoledronate Prevent Femoral Head Collapse from Osteonecrosis?: A Prospective, Randomized, Open-Label, Multicenter Study

Conclusions:
Zoledronate for Steinberg stage-I or II osteonecrosis of the femoral head, with a medium to large necrotic area, did not prevent the collapse of the femoral head or reduce the need for total hip arthroplasty.

Level of Evidence:
Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.

Source: The Journal of Bone and Joint Surgery - July 15, 2015 Category: Orthopaedics Authors: Lee, Y.-K., Ha, Y.-C., Cho, Y. J., Suh, K. T., Kim, S.-Y., Won, Y.-Y., Min, B.-W., Yoon, T. R., Kim, H. J., Koo, K.-H. Tags: Hip Scientific Articles Source Type: research