Diagnostic accuracy of fine needle aspiration cytology of thyroid and evaluation of discordant cases

Conclusion In spite of high accuracy of FNAC in differentiating between a benign and malignant lesion, certain pitfalls should be kept in mind. The common false negative diagnoses were follicular pattern cases which constitute a ‘gray zone’, cystic papillary thyroid carcinoma (PTC) and papillary microcarcinoma. The reason for false positive diagnoses was the occurrence of nuclear features characteristic of PTC in other thyroid lesions. Awareness of pathologist regarding these pitfalls can minimize false negative/positive diagnoses.
Source: Journal of the Egyptian National Cancer Institute - Category: Cancer & Oncology Source Type: research