Allopregnanolone Levels are Inversely Associated with Self‐Reported Pain Symptoms in U.S. Iraq and Afghanistan‐Era Veterans: Implications for Biomarkers and Therapeutics

ConclusionsThese findings are generally consistent with our prior pilot study and suggest that allopregnanolone may function as an endogenous analgesic. Thus, exogenous supplementation with allopregnanolone could have therapeutic potential. The characterization of neurosteroid profiles may also have biomarker utility.

Source: Pain Medicine - July 14, 2015 Category: Anesthesiology Authors: Jennifer C. Naylor, Jason D. Kilts, Steven T. Szabo, Charlotte E. Dunn, Francis J. Keefe, Larry A. Tupler, Lawrence J. Shampine, Rajendra A. Morey, Jennifer L. Strauss, Robert M. Hamer, H. Ryan Wagner, , Christine E. Marx Tags: Original Source Type: research