Comparative Analgesic Efficacy of Oxycodone/Acetaminophen vs Codeine/Acetaminophen for Short‐Term Pain Management Following ED Discharge

ConclusionOur hypothesis that oxycodone/acetaminophen provides analgesia superior to codeine/acetaminophen was rejected. Although pain within each group was reduced by more than half, the between‐group difference was not significant. Pending independent validation, these unexpected findings suggest that codeine/acetaminophen, a Schedule III agent, may be a clinically reasonable outpatient opioid alternative to oxycodone/acetaminophen, a more tightly restricted Schedule II agent thought to be more prone to misuse.

Source: Pain Medicine - July 14, 2015 Category: Anesthesiology Authors: Andrew K. Chang, Polly E. Bijur, Jason B. Lupow, E. John Gallagher Tags: Original Source Type: research