A manic episode with psychotic features improved by methylprednisolone in a patient with Multiple Sclerosis

Several studies have reported a higher prevalence of unipolar depression and bipolar disorder among patients with MS. However, only a few studies have reported manic episodes concomitant with new lesions enhanced by gadolinium on brain MRI. Here we report the case of a 47 year old woman suffering from MS admitted for a manic episode with psychotic features. Brain MRI revealed three new T2 lesions enhanced by gadolinium located in the corpus callosum and in ventromedial prefrontal regions. She rapidly recovered with intra-veinous methylprednisolone in combination with risperidone.
Source: General Hospital Psychiatry - Category: Psychiatry Authors: Source Type: research