Cardiotrophin-like cytokine factor 1 (CLCF1) and neuropoietin (NP) signalling and their roles in development, adulthood, cancer and degenerative disorders

Cardiotrophin-like-cytokine (CLCF1) and neuropoietin (NP) are the least defined of the four-helix bundle cytokines that signal through the gp130 receptor subunit. Until 10 years ago their main roles were thought to be restricted to the regulation of motor neuron development. However, more recent work has identified potential activities in adult biology, degenerative conditions and cancer, in a wide range of organ systems. In this review, I will describe what is currently known about the signalling complexes formed by these cytokines, and how their components overlap, as well as their known and postulated physiological and pathological functions.
Source: Cytokine and Growth Factor Reviews - Category: Molecular Biology Authors: Tags: Mini review Source Type: research