Emerging roles for IL-11 signaling in cancer development and progression: focus on breast cancer

Interleukin (IL)-11 is a member of the IL-6 family of cytokines that comprises nine secreted soluble ligands; IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin-M (OSM), ciliaryneurotrophic factor (CNTF), cardiotrophin-1 (CT-1), cardiotrophin-like cytokine (CLC), interleukin-27 (IL-27) and interleukin-31 (IL-31) [1–10]. Each ligand interacts with a specific non-catalytic transmembrane receptor or receptors, commonly referred to as the receptor alpha chain. Importantly, the family is defined by their shared use of the ubiquitously expressed transmembrane protein glycoprotein-130 beta-subunit (GP130, also known as IL6ST or CD130) [4,11,12].
Source: Cytokine and Growth Factor Reviews - Category: Molecular Biology Authors: Tags: Mini review Source Type: research