ERBB3 is required for tumor promotion in a mouse model of skin carcinogenesis

The epidermal growth factor receptor (EGFR) plays a key role in skin inflammation, wound healing, and carcinogenesis. Less is known about the functions of the structurally related receptor ERBB3 (HER3) in the skin. We assessed the requirement of ERBB3 for skin homeostasis, wound healing, and tumorigenesis by crossing mice carrying a conditional Erbb3 allele with animals expressing cre under the control of the keratin 5 promoter. Erbb3del mice, lacking ERBB3 specifically in keratinocytes, showed no obvious abnormalities.

Source: Molecular Oncology - July 3, 2015 Category: Cancer & Oncology Authors: Maik Dahlhoff, Matthias Schäfer, Sukalp Muzumdar, Christian Rose, Marlon R. Schneider Source Type: research