Retrospective biodosimetry using translocation frequency in a stable cell of occupationally exposed to ionizing radiation

In this study, while the frequency of reciprocal translocations was maintained at the initial level, dicentric chromosomes were decreased to 46.9% (31.0–76.5) of the initial frequency over the follow-up period. Our results support the long-term stability of reciprocal translocation through the cell cycle and validate the usefulness of translocation analysis as a retrospective biodosimetry for cases of occupational exposure.

Source: Journal of Radiation Research - July 9, 2015 Category: Physics Authors: Cho, M. S., Lee, J. K., Bae, K. S., Han, E.-A., Jang, S. J., Ha, W.-H., Lee, S.-S., Barquinero, J. F., Kim, W. T. Tags: Biology Source Type: research