Platelet-rich plasma releasate differently stimulates cellular commitment toward the chondrogenic lineage according to concentration

In conclusion, platelet-rich plasma releasate was able to prevent cellular chondrogenic capacity loss, inducing regain of their phenotype, and modulate cell commitment. Our data support the hypothesis of platelet-rich plasma chondrogenic potential, allowing fetal bovine serum substitution for platelet-rich plasma releasate at specific concentrations in culture medium when chondrogenic commitment is desired on specific cell types and moments of culture.

Source: Journal of Tissue Engineering - July 9, 2015 Category: Biotechnology Authors: do Amaral, R. J., Matsiko, A., Tomazette, M. R., Rocha, W. K., Cordeiro-Spinetti, E., Levingstone, T. J., Farina, M., O'Brien, F. J., El-Cheikh, M. C., Balduino, A. Tags: Original Article Source Type: research