Kv1.3 contains an alternative C-terminal ER exit motif and is recruited into COPII vesicles by Sec24a

Conclusion:
These results expand upon previous studies aimed at deciphering the Kv1.3 secretory trafficking mechanisms and further show in vitro evidence of the association between Kv1.3 and the COPII cargo adaptor subunit isoform Sec24a.

Source: BMC Biochemistry - July 10, 2015 Category: Biochemistry Authors: John SpearDolly KoborssyAustin SchwartzAdam JohnsonAnjon AudhyaDebra FadoolScott Stagg Source Type: research