Development and characterization of in-situ gel for ophthalmic formulation containing ciprofloxacin Hydrochloride

Publication date: Available online 8 July 2015 Source:Results in Pharma Sciences Author(s): S.B. Makwana , V.A. Patel , S.J. Parmar In situ gels are systems which are applied as solutions or suspensions and are capable of undergoing rapid sol-to-gel transformation triggered by external stimulus such as temperature, pH etc. on instillation. The aim of the present study was to formulate and evaluate pH responsive in-situ gel for ophthalmic delivery. Ciprofloxacin hydrochloride is popularly used as a broad spectrum anti biotic in the treatment of corneal ulcers of ocular infections. However, rapid dilution on instillation, wash out, poor retention of drug concentration delimit the therapeutic benefits of the drug when used in form of conventional eye drops. Sodium alginate, an ophthalmic gel forming mucoadhesive polymer was chosen as polymer which undergoes instantaneous gel formation due to formation of calcium alginate by virtue of its interaction with divalent Cation (ca+2) present in lachrymal fluid. Hydroxy Propyl Methyl Cellulose (HPMC K4M and E50LV) was further incorporated as a viscosity enhancer in order to achieve the desired consistency so as to facilitate sustained drug release. The developed formulations were evaluated for clarity, pH measurement, gelling capacity, drug content, rheological study, in vitro drug release. Thus, in situ gel based systems containing gums can be a valuable approach for ophthalmic drug delivery when compared to conventional system...
Source: Results in Pharma Sciences - Category: Drugs & Pharmacology Source Type: research