Oncostatin M and Interleukin-31: Cytokines, receptors, signal transduction and physiology

Even though the discovery of OSM dates back 25 years [1], its physiology and involvement in disease development are still incompletely understood. Initially discovered as a cytokine released from U937 cells which has cytostatic activities on the growth of melanoma cells, hence its name oncostatin M, it is now becoming clear that OSM has multiple functions in hematopoiesis, mesenchymal stem cell differentiation, liver regeneration, heart remodeling, nociceptive reception, inflammation and metabolism (Fig.
Source: Cytokine and Growth Factor Reviews - Category: Molecular Biology Authors: Tags: Survey Source Type: research