Mutations leading to constitutive active gp130/JAK1/STAT3 pathway

Constitutive activation of STAT (Signal Transducer and Activator of Transcription) proteins, and particularly of STAT3 and STAT5, is a common feature identified in numerous solid and hematological tumors [1,2].

Source: Cytokine and Growth Factor Reviews - July 3, 2015 Category: Molecular Biology Authors: Camilla Pilati, Jessica Zucman-Rossi Tags: Mini review Source Type: research