Transforming Growth Factor-β, MAPK and Wnt Signaling Interactions in Colorectal Cancer

Publication date: Available online 2 July 2015 Source:EuPA Open Proteomics Author(s): Harish R Cheruku , Abidali Mohamedali , David I Cantor , Sock Hwee Tan , Edouard C Nice , Mark S Baker In non-cancerous cells, transforming growth factor-β (TGFβ) regulates cellular responses primarily through Smad signaling. However, during cancer progression (including colorectal) TGFβ promotes tumoral growth via Smad-independent mechanisms and is involved in crosstalk with various pathways like the mitogen-activated protein kinases (MAPK) and Wnt. Crosstalk between these pathways following activation by TGFβ and subsequent downstream signaling activity can been referred to as a crosstalk signaling signature. This review highlights the progress in understanding TGFβ signaling crosstalk involving various MAPK pathway members (e.g., extracellular signal-regulated kinase (Erk) 1/2, Ras, c-Jun N-terminal kinases (JNK) and p38) and the Wnt signaling pathway. Graphical abstract
Source: EuPA Open Proteomics - Category: Bioinformatics Source Type: research