New insights into the nutritional regulation of gluconeogenesis in carnivorous rainbow trout (Oncorhynchus mykiss): a gene duplication trail

This study demonstrates that Ss4R in trout involved adaptive innovation via gene duplication and via the outcome of the resulting ohnologs. Indeed, maintenance of ohnologous g6pcb2 pair may contribute in a significant way to the glucose-intolerant phenotype of trout and may partially explain its poor use of dietary carbohydrates.

Source: Physiological Genomics - July 1, 2015 Category: Genetics & Stem Cells Authors: Marandel, L., Seiliez, I., Veron, V., Skiba-Cassy, S., Panserat, S. Tags: Nutrient Gene Interaction Source Type: research