Role of anoctamin-1 and bestrophin-1 in spinal nerve ligation-induced neuropathic pain in rats
Conclusions:
There is functional anoctamin-1 and bestrophin-1 expression in rats at sites related to nociceptive processing. Blockade of these CaCCs suppresses compound action potential generation in putative C fibers and lessens established tactile allodynia. As CaCCs activity contributes to neuropathic pain maintenance, selective inhibition of their activity may function as a tool to generate analgesia in nerve injury pain states.
Source: Molecular Pain - Category: Molecular Biology Authors: Jorge Pineda-FariasPaulino Barragán-IglesiasEmanuel Loeza-AlcocerJorge Torres-LópezHéctor Rocha-GonzálezFrancisca Pérez-SeverianoRodolfo Delgado-LezamaVinicio Granados-Soto Source Type: research
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