Carfilzomib-related acute kidney injury may be prevented by N-acetyl-L-cysteine

We describe a case of a 78-year-old man with refractory multiple myeloma with acute kidney injury associated with carfilzomib treatment. We show that use of N-acetyl-l-cysteine in our patient partially mitigated the renal injury upon re-challenge. This case report hypothesizes that acute renal injury from carfilzomib is caused by vasoconstriction of the renal vessels, which may be prevented by N-acetyl-l-cysteine.
Source: Journal of Oncology Pharmacy Practice - Category: Cancer & Oncology Authors: Tags: Case Reports Source Type: research