Experimental hyperlipidemia induces insulin resistance in sheep

This study aimed to evaluate the effects of intravenous infusion of a soybean based lipid emulsion on some blood energy-related metabolites and insulin sensitivity indexes in sheep. Four clinically healthy ewes were assigned into a 2-treatment, 2-period cross-over design. Either normal saline (NS) or lipid emulsion (LE), were intravenously introduced at a rate of 0.025 mL·kg-1·min-1 for 6 h. The concentrations of blood non-esterified fatty acid (NEFA), beta-hydroxybutyrate (BHB), triglyceride (TG), cholesterol, urea, creatinine, cortisol, glucose and insulin were measured at different time-points.
Source: Domestic Animal Endocrinology - Category: Endocrinology Authors: Source Type: research