Function and postnatal changes of dural afferent fibers expressing TRPM8 channels

Conclusions: Our results indicate that the TRPM8-expressing dural afferent fibers undergo cell- and target tissue-specific axonal pruning during postnatal development. Activation of dural TRPM8 channels decreases meningeal irritation-evoked nocifensive behavior in adult mice. This provides a framework to further explore the role of postnatal changes of TRPM8-expressing dural afferents in the pathophysiology of pediatric and adult migraine.
Source: Molecular Pain - Category: Molecular Biology Authors: Source Type: research