Ovariectomy-Induced Osteoporosis Does Not Impact Fusion Rates in a Recombinant Human Bone Morphogenetic Protein-2–Dependent Rat Posterolateral Arthrodesis Model

Conclusions This study demonstrates that estrogen deficiency and compromised bone quality do not negatively influence spinal fusion when utilizing rhBMP-2, and the osteoinductive capacity of the growth factor is not functionally reduced under osteoporotic conditions in the rat. Although osteoporosis is a risk factor for pseudarthrosis/nonunion, rhBMP-2-induced healing was not inhibited in osteoporotic rats.[...]Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  open access Full text

Source: Global Spine Journal - June 24, 2015 Category: Orthopaedics Authors: Ghodasra, Jason H.Nickoli, Michael S.Hashmi, Sohaib Z.Nelson, John T.Mendoza, MarcoNicolas, Joseph D.Bellary, Sharath S.Sonn, KevinAshtekar, AmrutaPark, Christian J.Babu, JacobYun, ChawonGhosh, AnjanKannan, AbhishekStock, Stuart R.Hsu, Wellington K.Hsu, E Tags: Original Article Source Type: research