Hepatocellular Carcinoma: Where There Is Unmet Need

Hepatocellular carcinoma (HCC) is a complex and heterogeneous tumor most commonly associated with underlying chronic liver disease, especially hepatitis. It is a growing problem in the United States and worldwide. There are two potential ways to prevent HCC. Primary prevention which is based on vaccination or secondary prevention involving agents that slows down carcinogenesis. Several pathways have been thought to play a role in the development of HCC; specifically, those involving vascular endothelial growth factor (VEGF)-mediated angiogenesis, WNT, phosphatidylinositol 3-kinase (PI3K) / AKT / mammalian target of rapamycin (mTOR), AMP-activated protein kinase (AMPK), and c-MET.

Source: Molecular Oncology - June 24, 2015 Category: Cancer & Oncology Authors: Manojkumar Bupathi, Ahmed Kaseb, Funda Meric-Bernstam, Aung Naing Source Type: research