Spinal cord stimulation modulates supraspinal centers of the descending antinociceptive system in rats with unilateral spinal nerve injury

Conclusions:
The serotonergic and noradrenergic pathways of the DAS are involved in the antinociceptive effect of SCS, but activation of the DRN might primarily be responsible for this effect, and the LC may have a smaller contribution. SCS does not potentiate the synthetic enzymes of 5HT and norepinephrine in the neuropathic spinal cord.

Source: Molecular Pain - June 24, 2015 Category: Molecular Biology Authors: Toshiharu TazawaYoshinori KamiyaAyako KobayashiKensuke SaekiMasahito TakiguchiYusuke NakahashiHironobu ShinboriKengo FunakoshiTakahisa Goto Source Type: research