Upregulation of cystathionine-beta-synthetase expression contributes to inflammatory pain in rat temporomandibular joint

Conclusion:
These data together with our previous report indicate that endogenous H2S generating enzyme CBS plays an important role in TMJ inflammation, which is likely mediated by inhibition of IK currents, thus identifying a specific molecular mechanism underlying pain and sensitization in TMJ inflammation.

Source: Molecular Pain - February 3, 2014 Category: Molecular Biology Authors: Xiuhua MiaoXiaowen MengGeping WuZhong JuHong-Hong ZhangShufen HuGuang-Yin Xu Source Type: research