Dynamic aberrant NF-κB spurs tumorigenesis: a new model encompassing the microenvironment

The role of transcription factor Nuclear Factor kappa B (“NF-κB”) in cell physiology has been reviewed extensively, and excellent articles describe mutations on genes that encode for NF-κB regulators in lymphoid malignancy [1]. Such mutations are relatively rare in solid tumors [2]. Lineages that give rise to solid tumors normally restrict their growth to generate solid tissue–this restriction can be overcome by NF-κB in carcinogenesis [3]. However, in recent years, study models for adenocarcinoma show oncogenes acting through NF-κB to cause cancer [1,4,5].

Source: Cytokine and Growth Factor Reviews - June 20, 2015 Category: Molecular Biology Authors: Spiros A. Vlahopoulos, Osman Cen, Nina Hengen, James Agan, Maria Moschovi, Elena Critselis, Maria Adamaki, Flora Bacopoulou, John A. Copland, Istvan Boldogh, Michael Karin, George P. Chrousos Source Type: research