Extracorporeal Machine Perfusion of the Pancreas: Technical Aspects and its Clinical Implications – A Systematic Review of Experimental Models

Pancreas or pancreatic islet transplantation is an important treatment option for insulin-dependent diabetes and its complications. However, as the pancreas is particularly susceptible to ischaemic-reperfusion injury, the criteria for pancreas and islet donation are especially strict. With a chronic shortage of donors, one critical challenge is to maximise organ availability and expand the donor pool. To achieve that, continuous improvement in organ preservation is required, with the aims of reducing ischaemia-reperfusion injury, prolong preservation time and improve graft function.
Source: Transplantation Reviews - Category: Transplant Surgery Authors: Source Type: research